Statistical membrane potential

Novel features of our potential:

  • Reference to the surface of membrane bilayer instead of the center
    --> Hydrophobic thickness dependence
  • Statistics of H-bonds in TMHs
    --> Additional terms for unpaired NH, CO
  • Derived from the most exposed 50% residues

    Our work is inspired by Chaim A. Schramm et. al. (Structure 20, 924-35).

     

    AA distributions

     

    Potential profile

     

     

    Insertion Protocol

    The optimal orietation and the hydrophobic thickness are determined by grid search.

     

    Insertion Protocol

     

     

    Returned results

     

     

    More details: poster @ 201706 Gorden Research Conference